I assumed you were getting downvoted initially for the disingenuous “both sides” rhetoric which is a non-point that has been gone over in detail here ad nauseum, and then subsequently because you doubled down by implying if people downvoted your first point, it means they think politicians have their best interests in mind. I don’t think anyone believes that, so it kind of reads like you’re tilting at windmills.
If he’s really dosing ketamine, it feels odd that he can’t seem to develop any sense of oneness with the universe, awareness of the innate value of other people, empathy for them, and self-humility. I guess it affects people differently, but what’s it actually doing for him?
It should say inflation-causing.
Really interesting! It makes me want to get scanned now bc I share a number of the same character traits that you mentioned. But, who knows how much that is just looking for a pattern/explanation or whether it’s even a common thing. Having some idea of the cost and maintenance of NMR and MRI machines, I don’t imagine many places offer walk-in elective scans for bargain prices.
If you don’t mind my asking, what were the circumstances that led to you getting an MRI, to even notice that?
If you do mind my asking, please let me know and I will continue to wonder.
They are not military, but they have had many huge military contracts over the years and work closely with the military. They also invented the microwave oven and many other commercial non-military electronics.
“It was a joke.” If you have to explain that something is a joke, you either need to work on your setup and delivery, or it’s only a joke in your own mind.
I would go even harder and say the formal/semi-formal/business/casual folkways are outdated and I wish those expectations or requirements didn’t exist. My work dress policy for the office doesn’t allow sweatpants or yoga pants, but jeans and khakis are fine if you aren’t “client-facing.” Fine, but in jeans or khakis I will be adjusting far more often and imo that’s less professional than just wearing more comfortable clothes.
“Underground economy.” Right…Nothing happens in China for long that the CCP doesn’t approve of, for a price.
You said, it is easy and inexpensive to manufacture generics and that the expense for drug production goes into research.
Did you not read the article you linked, or did you just not read my comment before downvoting it? It says the exact same thing in the “Controversies in FDA Bioequivalence Testing” section about the efficacy of the drug I listed as a specific example of generics not actually showing bioequivalence…TSH, free T4, and T3 in the blood are how the efficacy of levothyroxine is measured. Here, I’ll quote it for you.
Unresolved concerns surrounding bioequivalence undermine patients’ and health care providers’ confidence in making generic substitutions. Bioequivalence studies do not assess clinical or surrogate markers that directly correlate with efficacy and/or toxicity (e.g., thyroid-stimulating hormone [TSH], seizures, transplant rejection, international normalized ratio). In addition, manufacturers do not undertake comparative studies against other generic products with the same active ingredient, yet the FDA maintains that all approved generic medications are bioequivalent
That’s simply not true. Scale up and manufacturing of even the simplest small-molecule drugs even after all the clinical research has been completed is incredibly complex and hard to manufacture consistently, let alone replicate.
Even with access to all the research and manufacturing and quality testing procedures and records of a successfully manufactured drug (which a generic competitor would not have), I have seen and been part of an expansion facility at the very same location using the exact same raw material suppliers and exact same serial # equipment and even the same cleaning and manufacturing and quality testing lab employees just moved into a new building, take years and dozens of batches to get to the same level of consistent safety, identity, strength, purity, and quality as the previous manufacturing line after it was shut down to make room for a newer product. I’ve seen final product yield drop by nearly half from batch to batch just because the supplier of one raw material used as an excipient switched their own manufacturing process to make a powder slightly more consistently fine-grained and the mixing process no longer worked the same - and it took months of investigation to figure that out, plus much more time and money to find a solution and demonstrate it didn’t change the final product over the next three batches (a regulatory requirement).
Change over to modern large-molecule biologics where you have to grow them up in bioreactors, and things get a lot more complex to get it right and even harder to get consistent. You can’t just follow a recipe and double the ingredients to get twice the product.
Consider an extremely common drug like levothyroxine that’s been around for nearly a century and has many generic manufacturers because it’s one of the “easiest” and most well-understood essential drugs to make. It has such a low therapeutic window that the exact same process between two manufacturers, using the exact same raw material suppliers, passing testing with the exact same results, can result in such drastically inconsistent levels in the same patient at the exact same dose that many people are unable to switch from a one generic or brand manufacturer to another once their doctor has managed to find the right dose to keep their T4 levels stable. Something as mundane as the shape of the tablet press can make a huge difference even when dissolution is the same.
It’s not at all easy to manufacture drugs.
One of the dumbest social standards taught to kids that empowers bullies and bolsters peer pressure.
Yes, and also is fine if you’re using a cell hotspot.
You can also use network namespaces on Linux which Wireguard has a nice explanation and walkthrough on, recommending this as part of setting up wg connections. https://www.wireguard.com/netns/
Only 19 more to go.
What’s always been strange to me is that in three different cities in two different states, a large % of my local tax breakdown always says it’s going to the school district, which I am all for, but I think it’s all got to be going to building and ground maintenance. I’ve known teachers in my school districts (one with a master’s in education) with gross pay under $50k a year, who pay for classroom/teaching supplies out of pocket, and they’re teaching classes of 25-30 kids. I don’t have kids and probably never will, but I still want the kids in my school district to do well in school and have all the resources they need to become strong members of their communities when they grow up. Please raise my taxes if that’s what it takes to not fail another generation.
Putting a gun on a sink in the first place is so beyond dumb. He would have had to remove it from a secure place in his holster to do that, which would be dumb even if he was in a stall dropping trou to take a huge dump, but extra dumb when in a school. Nice to hear they actually got rid of at least one dangerous person before they could do something irreversibly tragic.
5k people is a bigger population than many towns yes, but crammed into a 250x250x1100 foot box in the biggest case (Ford class)